Evidence map›Paper›PMID 42012959›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Cell-type-resolved transcriptomic landscape of human focal cortical dysplasia.

Chuantao Fang, Yi Liu, Xiaodan Zhang, Ziwu Wang, Rongliang Guo, Jingjing Guo, Xianming Liu, Yanfeng Tan, Hao-Jie Lu, Rui Zhao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Cell-type-resolved transcriptomic landscape of human focal cortical dysplasia.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chuantao Fang *Center for Clinical Research and Translational Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.
Yi Liu *Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Science, Universidade de Vigo, Ourense 32004, Spain.
Xiaodan Zhang *Obstetrics and Gynecology Hospital of Fudan University, Fudan University, Shanghai 200032, China.
Ziwu Wang *State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Rongliang GuoDepartment of Central Laboratory, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, China.
Jingjing GuoCenter for Clinical Research and Translational Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.
Xianming LiuInstitutes of Biomedical Sciences and Department of Chemistry, Fudan University, Shanghai 200032, China.
Yanfeng TanInstitute of Pediatrics, Children's Hospital of Fudan University, Fudan University, Shanghai 200032, China.
Hao-Jie LuInstitutes of Biomedical Sciences and Department of Chemistry, Fudan University, Shanghai 200032, China.ORCID 0000-0003-3477-7662
Rui ZhaoDepartment of Neurosurgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China.ORCID 0009-0004-9444-571X
Guilin MengDepartment of Neurology, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200335, China.ORCID 0000-0002-4531-3938
Dashi QiCenter for Clinical Research and Translational Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.ORCID 0000-0002-0614-7068

Funding

MOST | National Natural Science Foundation of China (NSFC) 81500977
6 · The paper itself

Abstract

Focal cortical dysplasia (FCD) is a major cause of drug-resistant epilepsy and displays substantial clinical and histopathological heterogeneity, yet the cellular and molecular bases underlying this diversity remain poorly defined. Here, we performed single-nucleus RNA sequencing of 487,286 nuclei from 34 paired lesional cores and perilesional cortices across FCD I-III, generating a cell-type-resolved transcriptomic atlas of human FCD. Comparative analyses identified both shared and subtype-specific transcriptional alterations across neuronal, glial, and vascular compartments. Inhibitory interneurons and deep-layer projection neurons exhibited prominent dysregulation, whereas astrocytes and vascular cells showed coordinated activation of inflammatory, metabolic, and hypoxia-responsive pathways. Several genes displayed consistent subtype-associated expression patterns, including

Indexed as

Focal Cortical DysplasiaTranscriptomeAstrocytesFemaleGene Expression ProfilingHumansMaleNeuronsepilepsyFCD heterogeneityfocal cortical dysplasia (FCD)single-nucleus transcriptomicsvascular dysfunction

Identifiers

PMID42012959
PMCPMC13123813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.