Evidence map›Paper›PMID 42012956›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.

Cristina Colomer-Winter, Zeus J Nair, Jerome Y J Chua, Soukayna Jabli, Mélanie Roch, Amaury Cazenave-Gassiot, Roberto Sierra, Diego O Andrey, Shu-Sin Chng, Kimberly A Kline

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristina Colomer-WinterDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva 1211, Switzerland.ORCID 0000-0003-0103-4977
Zeus J NairSingapore-Massachusetts Institute of Technology Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Singapore 138602, Singapore.ORCID 0000-0001-9662-4958
Jerome Y J ChuaSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551, Singapore.
Soukayna JabliDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva 1211, Switzerland.ORCID 0009-0004-1257-9977
Mélanie RochDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva 1211, Switzerland.ORCID 0000-0001-6485-8434
Amaury Cazenave-GassiotSingapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore.ORCID 0000-0002-3050-634X
Roberto SierraDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva 1211, Switzerland.
Diego O AndreyDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva 1211, Switzerland.
Shu-Sin ChngDepartment of Chemistry, National University of Singapore, Singapore 117543, Singapore.ORCID 0000-0001-5466-7183
Kimberly A KlineDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva 1211, Switzerland.ORCID 0000-0002-5472-3074

Funding

Ministry of Education - Singapore (MOE) 2020-T1-002-103MOH | National Medical Research Council (NMRC) MOH-000645PMO | National Research Foundation Singapore (NRF) SCELSESchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 310030_219227Singapore-MIT Alliance for Research and Technology Centre (SMART) AMR IRGSociete Academique de Geneve SACAD
6 · The paper itself

Abstract

Daptomycin is a last resort antibiotic used to treat vancomycin-resistant enterococcal infections, but daptomycin resistance (DAP

Indexed as

Anti-Bacterial AgentsCell MembraneDaptomycinEnterococcus faecalisSignal TransductionBacterial ProteinsDrug Resistance, BacterialLipopolysaccharidesMembrane ProteinsTeichoic AcidsTransferases (Other Substituted Phosphate Groups)Anti-Bacterial AgentsBacterial Proteinscardiolipin synthetaseDaptomycinLipopolysaccharideslipoteichoic acidMembrane ProteinsTeichoic AcidsTransferases (Other Substituted Phosphate Groups)daptomycin resistanceEnterococcus faecalislipid remodelingLTAtwo-component systems

Identifiers

PMID42012956
PMCPMC13123819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.