Evidence map›Paper›PMID 42012953›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Two-dimensional NMR from a single pulse: Reconstructing heteronuclear 2D spectra via off-resonance decoupling and deep neural networks.

Nihar P Khandave, Veera Mohana Rao Kakita, Charles J Buchanan, Vaibhav Kumar Shukla, Kevin Haubrich, Pramodh Vallurupalli, D Flemming Hansen

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structural dynamics (Melville, N.Y.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nihar P KhandaveTata Institute of Fundamental Research, Gopanpally Village, Serilingampally Mandal, Ranga Reddy District, Hyderabad, Telangana 500107, India.
Veera Mohana Rao KakitaDepartment of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.ORCID 0009-0007-6635-955X
Charles J BuchananDepartment of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0002-1840-5706
Vaibhav Kumar ShuklaDepartment of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0001-5342-258X
Kevin HaubrichDepartment of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0001-5025-3821
Pramodh VallurupalliTata Institute of Fundamental Research, Gopanpally Village, Serilingampally Mandal, Ranga Reddy District, Hyderabad, Telangana 500107, India.ORCID 0000-0002-0936-6098
D Flemming HansenDepartment of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0003-0891-220X

Funding

DAE Government of India RTI 4007UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/R000255/1UKRI | Engineering and Physical Sciences Research Council (SRC) EP/X036782/1Wellcome Trust FC001029
6 · The paper itself

Abstract

NMR spectroscopy is ubiquitous in many areas of science, including chemistry, material science, biophysics, and structural biology. Heteronuclear two-dimensional (2D) NMR experiments form the basis of several NMR-based investigations, especially those involving biomolecules like proteins. However, in solution, as the molecule of interest becomes larger, transverse relaxation times of the spins of interest become shorter. This makes it difficult to record 2D

Indexed as

Neural Networks, ComputerNuclear Magnetic Resonance, BiomolecularProteinsCarbon IsotopesDeep LearningCarbon IsotopesProteinsdeep learninglarge proteinsmethyl groupsmulti-dimensional NMRsingle-pulse NMR

Identifiers

PMID42012953
PMCPMC13123836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.