Evidence map›Paper›PMID 42012949›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Emergence of genetic sex determination in an environmentally sex-determined animal.

Wen Wei, Man Lin, Trent Bishop, Ryan Shahriari, Yue Hao, Logan Graham, Bret L Coggins, Hannah Jee, Emma Fonseca, Swatantra Neupane and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wen WeiBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.ORCID 0000-0002-9734-1180
Man LinBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.ORCID 0009-0007-7485-3961
Trent BishopBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.
Ryan ShahriariBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.
Yue HaoBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.
Logan GrahamBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.ORCID 0009-0008-2997-5297
Bret L CogginsDepartment of Biological Sciences, Notre Dame University, Notre Dame, IN 46556.
Hannah JeeBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.
Emma FonsecaBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.
Swatantra NeupaneDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.ORCID 0000-0003-4709-764X
Li WangDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.
Sen XuDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.ORCID 0000-0002-1304-9968
Erin KimBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.
Michael LynchBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287.ORCID 0000-0002-1653-0642
Zhiqiang YeKey Laboratory of Pesticide and Chemical Biology of Ministry of Education, School of Life Sciences, Central China Normal University, Wuhan 430079, China.

Funding

Causes and Population-genetic Consequences of Molecular VariationR35GM122566 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael R LYNCH · 2017 to 2026
$7.7M
Understanding the origin of parthenogenesisR35GM133730 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI Sen Xu · 2019 to 2026
$2.7M
Population Genomics of Daphnia pulexR01GM101672 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI LYNCH, MICHAEL R · 2013 to 2016
$2.3M
Foundation for the NIH (FNIH) R35GM122566Foundation for the NIH (FNIH) R35GM133730MOST | National Natural Science Foundation of China (NSFC) Grant 32471695NIGMS NIH HHS R01 GM101672NIGMS NIH HHS R35 GM122566NIGMS NIH HHS R35 GM133730NSF | BIO | Division of Biological Infrastructure (DBI) DBI-2119963NSF (NSF) IOS-1922914NSF (NSF) IOS-2324639NSF (NSF) MCB-2348390
6 · The paper itself

Abstract

The evolution of genetic sex determination (GSD) from environmental sex determination (ESD) remains a fundamental issue in evolutionary biology. However, the mechanisms driving the transition, particularly in its earliest stages, are largely unknown. Here, we report a genetic variant in the ESD species,

Indexed as

DaphniaDaphnia pulexEnvironmentSex Determination ProcessesAnimalsEvolution, MolecularFemaleHaplotypesMaleRecombination, GeneticSex ChromosomesDaphniagynodioecysex-chromosome evolutionsex determinationstructural variation

Identifiers

PMID42012949
PMCPMC13123809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.