Evidence map›Paper›PMID 42012613›Full record

ArticleMagma (New York, N.Y.)2026

Multi-contrast dual-resolution UTE for myelin fraction mapping and structural imaging.

Nan Yin, Alexander Rau, Marco Reisert, Serhat Ilbey, Kian Tadjalli Mehr, Shuai Liu, Martin Helmstädter, Marius Schwabenland, Uzay Emir, Theo Demerath and 3 more

Abstract read
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In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nan YinDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany. nan.yin@uniklinik-freiburg.de.ORCID http://orcid.org/0009-0008-9690-7390
Alexander RauDepartment of Neuroradiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marco ReisertDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Serhat IlbeyDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Kian Tadjalli MehrDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Shuai LiuDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Martin HelmstädterDepartment of Nephrology and General Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marius SchwabenlandDepartment of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Uzay EmirDepartment of Radiology, University of North Carolina, Chapel Hill, NC, USA.
Theo DemerathDepartment of Neuroradiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Horst UrbachDepartment of Neuroradiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Michael BockDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Ali Caglar ÖzenDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

Funding

Deutsche Forschungsgemeinschaft 413517907Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg OEZ2257/24
6 · The paper itself

Abstract

purposeTo introduce and evaluate a novel multi-contrast dual-resolution 3D-UTE sequence (multi-UTE) for cerebral myelin fraction (MF) estimation in vivo and benchmark it against electron microscopy-based myelin volume fraction. THEORY AND

methodsDirect detection of myelin in tissue is challenging due to the ultrashort

resultsMulti-UTE facilitates the simultaneous acquisition of quantitative and structural images in 20 min. Myelin fraction values tested in five healthy volunteers agreed well with the literature. The MF estimated using multi-UTE showed a high correlation with histology (R

conclusionMulti-UTE showed the strongest correlations with electron microscopy (EM) histology, and the MF maps overlapped with the lesions in MS patients. Multi-UTE may provide complementary insights for myelin quantification in various inflammatory and neurodegenerative diseases.

Indexed as

MyelinNeurodegenerative diseasesQuantitative MRIUTE

Identifiers

PMID42012613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.