Evidence map›Paper›PMID 42012571›Full record

ReviewEJNMMI radiopharmacy and chemistry2026

Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective.

Julien Dubois, Emmanuel Deshayes, Florentin Kucharczak, Marine M Cadet, Jifang Zhou, Tom Paunet, Cyril Fersing

Abstract readReview
In one paragraph

Review in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julien DuboisRadiopharmacy Department, Montpellier University Hospital, Univ Montpellier, Montpellier, France. julien-dubois@chu-montpellier.fr.ORCID http://orcid.org/0009-0007-1046-3200
Emmanuel DeshayesIRCM, Univ Montpellier, ICM, INSERM, Montpellier, France.
Florentin KucharczakNuclear Medicine Department, Montpellier University Hospital, Univ Montpellier, Montpellier, France.
Marine M CadetRadiopharmacy Department, Montpellier University Hospital, Univ Montpellier, Montpellier, France.
Jifang ZhouSchool of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China.
Tom PaunetNuclear Medicine Department, Montpellier University Hospital, Univ Montpellier, Montpellier, France.
Cyril FersingNuclear Medicine Department, Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmuno-positron emission tomography (immuno-PET) imaging is emerging as a highly promising technique for the non-invasive diagnosis of a wide range of pathological conditions, particularly in oncology and immunology. This molecular imaging modality enables the visualization, characterization, and quantification of biological processes at a cellular and molecular level. MAIN BODY: Immuno-PET relies mostly on the administration of monoclonal antibodies (mAb) labeled with positron-emitting radionuclides. These antibodies are specifically designed to bind to antigens that are overexpressed on tumor cells or involved in pathological non-neoplastic processes, such as inflammatory or autoimmune diseases. Numerous disease-associated antigens have been identified and are currently being explored as potential molecular targets for immuno-PET, paving the way for more personalized diagnostic and treatment approaches. This technique offers significant potential in the context of theranostic, as it allows for the simultaneous assessment of both diagnostic and therapeutic parameters. It is particularly useful for predicting and monitoring the pharmacokinetics and biodistribution of targeted therapies, thereby helping to optimize therapeutic efficacy while minimizing adverse effects. Among the various radioisotopes available, zirconium-89 (

conclusionIn this review, we aim to provide an overview of the current clinical applications of

Indexed as

89ZrClinical trialsImmuno-PETRadiopharmaceuticalsZirconium-89

Identifiers

PMID42012571
PMCPMC13100247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.