SynthesisBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2026
Efficiency of Commercial and Test Vaccines Against Lawsonia intracellularis on Clinical and Immunological Parameters in Swine: A Systematic Review.
Synthesis in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lawsonia intracellularis is a gram-negative obligate intracellular bacterium causing Proliferative Enteropathy in pigs, leading to significant economic losses in the swine industry. Vaccination offers an alternative to antibiotics for controlling this pathogen. This systematic review evaluates the efficacy of commercial and experimental vaccines against Lawsonia intracellularis in pigs, focusing on clinical outcomes and immunological responses. Following PRISMA guidelines, databases including PubMed, Google Scholar, CABI Digital Library, and Agricola/USDA were searched for studies from the past decade. Selected studies were assessed for bias using SYRCLE’s RoB tool. Data on weight gain, pathogen shedding, mortality, and immune responses were extracted and analyzed. Out of 824 identified articles, 9 studies met the inclusion criteria. Results indicated that vaccinated pigs showed reduced fecal shedding of L. intracellularis, lower mortality rates, and enhanced immune responses compared to non-vaccinated controls. Specific vaccines increased IFN-γ production, a crucial cytokine for Th1 responses against intracellular pathogens. Vaccination is an effective strategy to control Lawsonia intracellularis infection in swine, reducing disease symptoms and transmission. Continued research is necessary to optimize vaccination protocols and assess long-term economic impacts.
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