ArticlePediatric surgery international2026
Analysis of terminal rectal fibrosis and expression of type I and type III collagen proteins in patients with mid-high anorectal malformations.
Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with intermediate and high-type anorectal malformations (ARMs) demonstrate moderate to severe fibrosis in the distal rectal wall, which may underlie postoperative defecation dysfunction. This study aims to systematically evaluate and quantitatively analyze collagen deposition patterns in the distal rectal wall, providing new insights into the mechanism of defecation disorders following anorectal reconstruction.
methodsWe conducted an integrated analysis of 30 intermediate/high-type ARMs patients utilizing histochemical staining, immunohistochemistry, and Western blot to quantitatively evaluate spatial extracellular matrix (ECM) composition and fibrotic architecture in the distal rectal wall.
resultsMicroscopic examination revealed densely packed collagen fibers within the submucosal layer and prominent perineural collagen deposition surrounding the myenteric plexus in distal segments. Quantitative analysis demonstrated significantly greater perineural connective tissue thickness in distal versus proximal intestinal wall (P < 0.001). Both type I (P < 0.001) and type III (P = 0.039) collagen expression were significantly elevated in distal segments, with a notably increased type I/III collagen ratio (P = 0.014).
conclusionThe distal rectal wall in intermediate and high-type ARMs patients exhibits abnormal ECM deposition characterized by significantly increased type I and III collagen, with predominant type I collagen elevation. These findings suggest a mature, stiffened fibrotic phenotype with impaired tissue compliance and structural irreversibility. The distinctive collagen deposition profile identified in this study may be critically associated with the pathogenesis of postoperative defecation dysfunction in ARM patients.
Indexed as
Identifiers
42012515What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.