ArticleJournal of neurophysiology2026
Impact of tongue exercise on hypoglossal axis survival, structure, and output in a rodent model of hypoglossal motor neuron degeneration.
Article in Journal of neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Motor neuron diseases (MNDs) are progressive neurological disorders in which motor neurons necessary for walking, swallowing, and breathing are destroyed. Obstructive sleep apnea (OSA) occurs more commonly in patients with MNDs and may contribute to disease progression. Intralingual injections of cholera toxin B conjugated to saporin (CTB-SAP) mimic hypoglossal (XII) motor neuron loss observed in MND models and result in airway deficits observed in MNDs and OSA, often leading to respiratory failure and death. Using this model, we investigated the effects of a high-repetition/low-resistance tongue exercise paradigm on XII axis survival, structure, and output in adult male Sprague-Dawley rats. Rats were allocated to four experimental groups that received intralingual injection of either CTB-SAP or unconjugated CTB + SAP (i.e., control) ± tongue exercise. Following tongue exercise exposure, we evaluated motor neuron survival in the primary motor cortex and XII nucleus, and glial density in the XII nucleus with immunohistochemistry, ultrastructural XII nerve changes with transmission electron microscopy (TEM), and XII motor output in anesthetized rats using in vivo neurophysiology. Results revealed that
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.