Evidence map›Paper›PMID 42012452›Full record

ArticleFuture science OA2026

Severe numbness of the mouth and tongue induced by piperacillin/tazobactam: a rare case report.

Xinqi Huang, Wanlin Liu, Bo Tan, Lichuan Shi, Yongliang Huang, Shuting Wang, Nianqing Yin, Yi Li, Liutao Zheng, Yanli Dai

Abstract read
In one paragraph

Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinqi HuangDepartment of Pharmacy, Traditional Chinese Medicine Hospital of Meishan.ORCID 0009-0000-1841-2458
Wanlin LiuDepartment of Anesthesia Surgery Center, Sichuan Provincial People's Hospital.ORCID 0009-0005-0361-001X
Bo TanDepartment of Pharmacy, Pengzhou People's Hospital.ORCID 0009-0008-6470-3748
Lichuan ShiDepartment of Pharmacy, Jintang County Maternal and Child Health Hospital.ORCID 0009-0000-4731-2245
Yongliang HuangDepartment of Pharmacy, Hospital of Chengdu University of Traditional Chinese Medicine.ORCID 0000-0002-2673-5027
Shuting WangDepartment of Pharmacy, Pengzhou Hospital of Traditional Chinese Medicine.ORCID 0009-0002-3217-6732
Nianqing YinDepartment of Pharmacy, Pengzhou Hospital of Traditional Chinese Medicine.ORCID 0009-0005-1024-9808
Yi LiDepartment of Pharmacy, Pengzhou Hospital of Traditional Chinese Medicine.ORCID 0009-0002-4763-0811
Liutao ZhengDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine.ORCID 0009-0008-0369-8906
Yanli DaiDepartment of Pharmacy, Traditional Chinese Medicine Hospital of Meishan.ORCID 0009-0002-4177-0469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere oral and tongue numbness induced by piperacillin/tazobactam is extremely rare.

resultsA 58-year-old man with bacterial pneumonia developed oral and tongue numbness, dyspnea, and pruritus approximately 4 minutes after intravenous infusion of piperacillin/tazobactam. Based on adverse drug reaction causality assessment, this event was identified as a previously unreported severe adverse drug reaction. DISCUSSION: This case suggests that during clinical use of piperacillin/tazobactam, clinicians should remain vigilant for rare but severe adverse drug reactions even when skin testing is negative, and strengthen medication monitoring to ensure medication safety.

Indexed as

adverse drug reactionshypersensitivitynumbness of mouth and tonguePiperacillin/tazobactamsusceptibility factors

Identifiers

PMID42012452
PMCPMC13102034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.