ArticleJACC. Case reports2026
Reversible Chronotropic Incompetence in Early Cardiac Sarcoidosis Assessed by Serial Exercise Echocardiography.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCardiac sarcoidosis (CS) can cause conduction disturbances and heart failure. Chronotropic incompetence due to atrioventricular (AV) conduction abnormalities may represent an early and potentially reversible manifestation of CS. CASE SUMMARY: A 62-year-old woman with suspected CS presented with exertional dyspnea and exercise-induced second-degree AV block. Despite preserved left ventricular systolic function at rest, cardiopulmonary exercise testing combined with exercise echocardiography revealed a severely impaired chronotropic response and inadequate cardiac output augmentation. DISCUSSION: Chronotropic incompetence due to reversible AV conduction delay may occur as an early manifestation of CS and improve with timely corticosteroid therapy. TAKE-HOME MESSAGE: Serial exercise echocardiography quantifies chronotropic and hemodynamic recovery during corticosteroid therapy and aids early detection of cardiac sarcoidosis.
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