Evidence map›Paper›PMID 42012401›Full record

ReviewACS nano2026

Super-Resolution Structured Illumination Microscopy to Study Endocytosis and Cellular Nanoparticle Uptake.

Yicong Wu, Piotr Grodzinski

Abstract readReview
In one paragraph

Review in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yicong WuNanodelivery Systems and Devices Branch, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-8819-7527
Piotr GrodzinskiNanodelivery Systems and Devices Branch, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-2245-9870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineering nanoparticles for cancer intervention requires a detailed understanding of their internalization and intracellular trafficking, as these processes ultimately determine delivery efficiency. Over the past decade, advances in labeling strategies and microscopy have significantly deepened our knowledge of these processes. Further progress is imminent, as super-resolution microscopy has shattered the diffraction limit, enabling the investigation of biological structures at scales as small as ∼10 nm. Among the various super-resolution techniques used to interrogate endocytosis, super-resolution structured illumination microscopy (SR-SIM) stands out for its ability to provide faster, gentler imaging in live specimens. In this review, we will highlight how SR-SIM has enabled in-depth investigation of intracellular processes ranging from endocytic coat formation to endosomal maturation and therapeutic targeting. With the increasing popularity of SR-SIM in the biological sciences, this review aims to serve as a practical guide to its emerging applications, particularly in elucidating the endocytosis and intracellular trafficking of therapeutic nanomedicines.

Indexed as

EndocytosisMicroscopyNanoparticlesAnimalsEndosomesHumansMicroscopy, Fluorescencedrug deliveryendocytosisendosomal escapeintracellular traffickingnanomedicinesnanoparticlesstructured illumination microscopysubcellular localizationsuper-resolution

Identifiers

PMID42012401
PMCPMC13151065

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.