Evidence map›Paper›PMID 42012259›Full record

ArticleMicrobiology spectrum2026

Human natural killer cells exhibit potent antifungal activity against azole-resistant

Hotaka Namie, Takahiro Takazono, Satoshi Irifune, Satoru Koga, Yuya Ito, Nana Nakada, Tatsuro Hirayama, Masataka Yoshida, Kazuaki Takeda, Shotaro Ide and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hotaka NamieDepartment of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.ORCID 0009-0002-2561-1644
Takahiro TakazonoDepartment of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.ORCID 0000-0002-0696-5386
Satoshi IrifuneDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Satoru KogaJapanese Red Cross Nagasaki Genbaku Isahaya Hospital, Isahaya city, Nagasaki, Japan.
Yuya ItoDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Nana NakadaHealth Center, Nagasaki University, Nagasaki City, Nagasaki, Japan.
Tatsuro HirayamaDepartment of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
Masataka YoshidaDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Kazuaki TakedaDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Shotaro IdeInfectious Diseases Experts Training Center, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Naoki IwanagaDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.ORCID 0000-0002-0680-390X
Masato TashiroDepartment of Infectious Disease Medicine, Yokohama City University Graduate School of Medicine, Yokohama City, Kanagawa, Japan.ORCID 0000-0001-7609-7679
Naoki HosogayaClinical Research Center, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Noriho SakamotoDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Haruki OkamuraLaboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Nishinomiya, Japan.
Yoshimasa TanakaCenter for Medical Innovation, Nagasaki University, Nagasaki City, Nagasaki, Japan.
Katsunori YanagiharaDepartment of Laboratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Tomoya NishinoDepartment of Nephrology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Hiroshi MukaeDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
Koichi IzumikawaDepartment of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.

Funding

Japan Agency for Medical Research and Development 22fk0108530h0001Japan Agency for Medical Research and Development A48 and A90Japan Society for the Promotion of Science 23K07941Ministry of Education, Culture, Sports, Science and Technology 16K08844, 23K06677, JP223fa627004Support Program for Starting up Innovation Hub JPMJST2281
6 · The paper itself

Abstract

Invasive aspergillosis in immunocompromised individuals is associated with a poor prognosis. Recently, the global emergence of azole-resistant

Indexed as

Antifungal AgentsAspergillus fumigatusAzolesDrug Resistance, FungalFungiKiller Cells, NaturalAspergillosisCoculture TechniquesHumansAntifungal AgentsAzolesazole resistancefilamentous fungiinterferon-γinvasive aspergillosisNK cellXTT assay

Identifiers

PMID42012259
PMCPMC13227959

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.