ArticleJournal of virology2026
The oral nucleoside analogue inhibitor VV251 effectively inhibits coinfection by respiratory syncytial virus and influenza A virus.
Ruxue Zhang, Xiaoqin Jian, Yumin Zhang, Yuan Sun, Mengwei Xu, Junyuan Cao, Guanghui Tian, Li Xiang, Jiangshan Shen, Gengfu Xiao and 2 more
Abstract read
In one paragraphArticle in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Ruxue Zhang *State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.ORCID 0000-0002-2518-6185 Xiaoqin Jian *State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.
Yumin ZhangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.
Yuan SunState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.ORCID 0000-0001-8244-7436 Mengwei XuState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.
Junyuan CaoState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.
Guanghui TianVigonvita Shanghai Co., Ltd., Shanghai, China.
Li XiangState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China.ORCID 0009-0009-4470-2315 Gengfu XiaoState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.
Tianwen HuVigonvita Shanghai Co., Ltd., Shanghai, China.
Leike ZhangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Center for Biosafety Mega-Science, Wuhan, Hubei, China.ORCID 0000-0002-2593-2571 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Respiratory syncytial virus (RSV) and influenza virus are the principal contributors to respiratory tract infections worldwide. Clinical treatment of RSV or influenza A virus (IAV) is limited and may be postponed because of misdiagnosis or coinfection with multiple pathogens. Here, we described VV251, the prodrug of 4'-fluorouridine, a novel oral nucleoside analog that exhibits potent inhibitory activity against RSV laboratory strains and clinical isolates, as well as IAV,
Indexed as
Antiviral AgentsCoinfectionInfluenza A virusOrthomyxoviridae InfectionsRespiratory Syncytial Virus InfectionsUridineAdministration, OralAnimalsDeoxycytidineDisease Models, AnimalDogsFemaleHumansMadin Darby Canine Kidney CellsMiceMice, Inbred BALB C4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidineAntiviral AgentsDeoxycytidineUridinecoinfection treatmentinfluenza A virusrespiratory syncytial virusVV251
Identifiers
PMID42012186
PMCPMC13185581
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390