Evidence map›Paper›PMID 42012061›Full record

ArticleEnvironmental science & technology2026

Accounting for Differences in Plasma Protein Binding between Fish and Humans for Supporting Environmental Risk Assessment of Pharmaceuticals Using the Fish Plasma Model.

A Ross Brown, Maciej Trznadel, Siffreya Pedersen, Alison Nimrod Perkins, Michael Lee, Michael Mohutsky, Alec Bell, Tea Lm Pihlaja, Tiina Sikanen, Mirco Weil and 3 more

Abstract read
In one paragraph

Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Environmental science & technology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

A Ross BrownBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom.ORCID 0000-0002-3892-8993
Maciej TrznadelBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom.
Siffreya PedersenBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom.
Alison Nimrod PerkinsEli Lilly and Company, Indianapolis, Indiana 46285, United States.
Michael LeeEli Lilly and Company, Indianapolis, Indiana 46285, United States.
Michael MohutskyEli Lilly and Company, Indianapolis, Indiana 46285, United States.
Alec BellEli Lilly and Company, Indianapolis, Indiana 46285, United States.
Tea Lm PihlajaFaculty of Pharmacy, University of Helsinki, PL 56, Viikinkaari 5, Helsinki 00014, Finland.
Tiina SikanenFaculty of Pharmacy, University of Helsinki, PL 56, Viikinkaari 5, Helsinki 00014, Finland.ORCID 0000-0002-0788-1301
Mirco WeilECT Oekotoxikologie GmbH, Boettgerstr. 2-14, Floersheim/Main 65439, Germany.
Anja CoorsBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom.ORCID 0000-0002-9224-2917
Rod W WilsonBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom.
Charles R TylerBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Fish Plasma Model (FPM) predicts steady-state concentrations of active pharmaceutical ingredients (APIs) in fish blood plasma based on partitioning from the surrounding (water) environment. Total plasma concentration is then compared to the human therapeutic concentration to indicate environmental risk, assuming that human pharmaceutical targets are conserved in fish. However, only the unbound fraction (f

Indexed as

Blood ProteinsFishesAnimalsHumansOncorhynchus mykissPharmaceutical PreparationsProtein BindingRisk AssessmentBlood ProteinsPharmaceutical PreparationsAGPalbuminapolipoproteinsblood plasmacyprinid fishionizable pharmaceuticalssalmonid fish

Identifiers

PMID42012061
PMCPMC13151045

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.