Evidence map›Paper›PMID 42012056›Full record

ArticleChemical research in toxicology2026

Modulation of ER Stress via cAMP Signaling: Protective Role of Rolipram in Paracetamol-Induced Liver Injury.

Saziye Sezin Palabiyik-Yucelik, Nagihan Demirtas, Nevra Aydemir Celep, Ayse Bozkurt, Zekai Halici, Elif Cadirci

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saziye Sezin Palabiyik-YucelikFaculty of Pharmacy, Department of Pharmaceutical Toxicology, Ondokuz Mayıs University, Samsun 55400, Turkey.
Nagihan DemirtasFaculty of Pharmacy, Department of Pharmaceutical Toxicology, Atatürk University, Erzurum 25240, Turkey.
Nevra Aydemir CelepFaculty of Medicine, Department of Medical Pharmacology, Atatürk University, Erzurum 25240, Turkey.
Ayse BozkurtFaculty of Pharmacy, Department of Pharmacology, Van Yüzüncü Yıl University, Van 65080, Turkey.
Zekai HaliciFaculty of Medicine, Department of Medical Pharmacology, Atatürk University, Erzurum 25240, Turkey.
Elif CadirciFaculty of Medicine, Department of Medical Pharmacology, Atatürk University, Erzurum 25240, Turkey.ORCID 0000-0003-0836-7205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This investigation sought to assess the potential protective function of the phosphodiesterase-4 (PDE) enzyme inhibitor rolipram (ROL) against paracetamol (PARA) induced liver damage, as well as any potential underlying mechanism through modulation of endoplasmic reticulum (ER) stress via cAMP signaling. Fifty-six rats were randomly divided into 7 groups (

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryCyclic AMPEndoplasmic Reticulum StressPhosphodiesterase 4 InhibitorsProtective AgentsRolipramSignal TransductionAnimalsEndoplasmic Reticulum Chaperone BiPLiverMaleRatsRats, WistarAcetaminophenCyclic AMPEndoplasmic Reticulum Chaperone BiPPhosphodiesterase 4 InhibitorsProtective AgentsRolipram

Identifiers

PMID42012056
PMCPMC13188158

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.