Evidence map›Paper›PMID 42011799›Full record

ArticleInternal medicine journal2026

Caring for Australians and New ZealandeRs with kidney Impairment guideline commentary on kidney disease: improving global outcomes 2025 guidelines for diagnosis and management of autosomal polycystic kidney disease.

Mia E Abdy, Kitty St Pierre, Emily Major, Stephen I Alexander, Brydee Cashmore, Helen Coolican, Vanessa Cullen, Jessica Dawson, Kelly Lambert, Vincent W Lee and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mia E AbdySydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0000-8464-6711
Kitty St PierreSchool of Pharmacy and Medical Sciences, Griffith University, Southport, Australia.ORCID https://orcid.org/0000-0002-0809-5054
Emily MajorDepartment of Microbiology, Anatomy, Physiology, and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.
Stephen I AlexanderCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-3609-4446
Brydee CashmoreSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-2230-5350
Helen CoolicanCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Vanessa CullenCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Jessica DawsonNHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9925-745X
Kelly LambertSchool of Medical, Indigenous and Health Sciences, University of Wollongong, New South Wales, Australia.ORCID https://orcid.org/0000-0001-5935-7328
Vincent W LeeCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9400-3696
Amali MallawaarachiDivision of Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-1229-1701
Gopala RanganDepartment of Renal Medicine, Westmead Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-2147-0998
Judy SavigeMelbourne Health and Northern Health, Royal Melbourne Hospital, The University of Melbourne Department of Medicine, Parkville, Australia.ORCID https://orcid.org/0000-0002-6813-0288
Santosh VarugheseMelbourne Health and Northern Health, Royal Melbourne Hospital, The University of Melbourne Department of Medicine, Parkville, Australia.
David J TunnicliffeSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-3270-3475
Andrew J MallettDepartment of Renal Medicine, Townsville University Hospital, Townsville, Queensland, Australia.ORCID https://orcid.org/0000-0002-8752-2551
CARI Guidelines Steering Committee

Funding

PKD Australia Early Career Researcher Grant 2025
6 · The paper itself

Abstract

Autosomal polycystic kidney disease (ADPKD) is the most common form of inherited kidney disease. The international guideline developer, Kidney Disease: Improving Global Outcomes (KDIGO), published a 2025 clinical practice guideline reflecting advances in genetic testing and the first disease-modifying agent, tolvaptan. However, KDIGO guidelines do not address healthcare access or equity issues relevant to the needs of our populations in Australia and New Zealand. The Caring for Australians and New ZealandeRs with kidney Impairment (CARI) Guidelines Working Group has provided a regional commentary to contextualise the KDIGO 2025 ADPKD guideline. This commentary aims to support clinicians in applying the KDIGO ADPKD 2025 guidance within our local health systems and highlights challenges in the implementation, including public subsidy limitations for recommended genetic testing and treatments. It also addresses equity concerns such as rural and remoteness, ensuring guidance is relevant to Australia and New Zealand.

Indexed as

Polycystic Kidney, Autosomal DominantPractice Guidelines as TopicAustralasian PeopleAustraliaDisease ManagementGenetic TestingHumansNew Zealandautosomal‐dominant polycystic kidney diseaseclinical practice guidelinesevidence‐based medicinenephrology

Identifiers

PMID42011799
PMCPMC13288312

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.