Evidence map›Paper›PMID 42011768›Full record

ArticleCancer2026

Intratumoral fungal burden of Candida tropicalis as a novel prognostic biomarker for recurrence and mortality in colorectal cancer.

Sakiko Oba, Keisuke Okuno, Shuichi Watanabe, Yudai Yamamoto, Ayumi Takaoka, Marie Hanaoka, Shinichi Yamauchi, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban and 1 more

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Article in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sakiko ObaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Keisuke OkunoDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0009-0009-6964-2726
Shuichi WatanabeDepartment of Hepatobiliary and Pancreatic Surgery, Institute of Science Tokyo, Tokyo, Japan.
Yudai YamamotoDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Ayumi TakaokaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Marie HanaokaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Shinichi YamauchiDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Hiroyasu KagawaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Masanori TokunagaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Daisuke BanDepartment of Hepatobiliary and Pancreatic Surgery, Institute of Science Tokyo, Tokyo, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.

Funding

Japan Society for the Promotion of Science JP23K19499Japan Society for the Promotion of Science JP24K18571Kobayashi Foundation for Cancer Research 2023DI008
6 · The paper itself

Abstract

backgroundThe crucial role of gut fungus dysbiosis in the carcinogenesis and progression of colorectal cancer (CRC) has recently garnered increasing attention. In this study, the potential role of Candida tropicalis, commensal gut fungi, in predicting CRC prognosis was investigated.

methodsA total of 304 frozen surgical cancer tissue specimens were obtained from patients with CRC and evaluated the intratumoral C. tropicalis burden using quantitative polymerase chain reaction assays. Mycobial composition and diversity analyses were performed by analyzing publicly available metagenomic datasets.

resultsMetagenomic dataset analysis revealed significant differences in fungal composition and diversity of Candida species among adjacent normal and CRC tissues. The 5-year recurrence-free survival and disease-specific survival rates were significantly worse in patients with a high intratumoral C. tropicalis burden than in those with a low burden (78.0% vs. 86.6%; p = .03 and 88.9% vs. 98.0%; p < .01, respectively). Furthermore, multivariate Cox regression analysis revealed that increased intratumoral C. tropicalis burden was a significant independent predictor for recurrence-free survival (hazard ratio [HR]: 1.92; 95% CI, 1.08-3.44; p = .03) and disease-specific survival (HR: 4.29; 95% CI, 1.36-13.5; p = .03).

conclusionsThese results have demonstrated, possibly for the first time, the potential of intratumoral C. tropicalis burden as a novel prognostic biomarker for recurrence and mortality in patients with CRC.

Indexed as

Candida tropicalisColorectal NeoplasmsNeoplasm Recurrence, LocalAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedPrognosisBiomarkers, TumorCandida tropicaliscolorectal cancerfungusmycobiomeprognostic biomarker

Identifiers

PMID42011768
PMCPMC13097085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.