Evidence map›Paper›PMID 42011761›Full record

ArticleZoological research2026

Tubulin hyperglutamylation induces retinal degeneration by disrupting ciliary architecture and protein trafficking.

Hao-Lin Wang, Ting Wang, Fang-Yuan Zhen, Yong-Qiong Lin, Ying-Jie Tong, Jia-Hui Wu, Jia-Xin Guo, Jia-Jia Wang, Shu-Qian Dong, Carsten Janke and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hao-Lin WangGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Ting WangGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Fang-Yuan ZhenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China.
Yong-Qiong LinGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Ying-Jie TongGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Jia-Hui WuDepartment of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Henan Provincial Ophthalmic Hospital, Zhengzhou, Henan 450052, China.
Jia-Xin GuoGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Jia-Jia WangGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Shu-Qian DongDepartment of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Henan Provincial Ophthalmic Hospital, Zhengzhou, Henan 450052, China.
Carsten JankeInstitut Curie, PSL Research University, Orsay, CNRS UMR3348, France.
Maria M MagieraInstitut Curie, PSL Research University, Orsay, CNRS UMR3348, France.
Hou-Bin ZhangGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Tong-Dan ZouGenetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China. E-mail: 1147726445@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tubulin post-translational modifications confer diverse functions to microtubules, with polyglutamylation representing a dynamic modification governed by coordinated glutamylation and deglutamylation. AGBL5 functions as a deglutamylase that removes glutamate residues at branch points within polyglutamate chains. While pathogenic variants in human

Indexed as

CiliaPeptide SynthasesRetinal DegenerationTubulinAnimalsMiceMice, KnockoutProtein TransportPeptide SynthasesTubulintubulin polyglutamylaseAGBL5Connecting ciliumIntraflagellar transportPhotoreceptorRetinal degenerationTubulin glutamylation

Identifiers

PMID42011761
PMCPMC13425397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.