Observational studyCancer control : journal of the Moffitt Cancer Center
Trends in the Incidence of Human Papillomavirus-Related Cancers in Canada and the Netherlands.
Observational study in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IntroductionHuman papillomavirus (HPV) is a well-established cause of cervical cancer and is increasingly recognized as an important risk factor for non-cervical cancers, including oropharyngeal, anal, vulvar, vaginal, and penile cancers. This study assessed temporal trends in the incidence of HPV-related cervical and non-cervical cancers in Canada and the Netherlands by sex assigned at birth and cancer type using population-based registry data.MethodsThis study is a registry-based observational study, in which we analyzed retrospective data from the Canadian Cancer Registry (1992-2022) and the Netherlands Cancer Registry (2000-2019) for HPV-related cancers. Age-standardized incidence rates, annual percentage changes (APC), and average annual percentage changes (AAPC), with corresponding 95% confidence intervals (95% CI), were estimated using Joinpoint regression.ResultsIn Canada, cervical cancer incidence rate generally declined since 1992 but has increased by 1.1% (0.5, 2.7) annually between 2013 and 2022. In the Netherlands, cervical cancer rates remained stable until 2015, followed by a 5.1% (1.9, 11.5) annual increase between 2015 and 2019. Non-cervical HPV-related cancers generally increased in both countries. In Canada, from 1992 to 2022, incidence rates increased for oropharyngeal (AAPC: 2.0% [1.6, 2.4]), anal (1.7% [1.3, 2.2]), and vulvovaginal (1.9% [1.6, 2.3]) cancers. In the Netherlands, from 2000 to 2019, incidence rates increased for anal (5.3% [4.2, 6.8]), vulvar (3.0% [2.2, 4.0]), penile cancers (2.8% [1.7, 4.0]), and oropharyngeal cancer (0.7% [0.1, 1.2]).ConclusionIn general, we observed similar trends in both countries: that the incidence of HPV-related cervical and non-cervical cancers in Canada and the Netherlands is rising. These findings highlight the need to expand HPV vaccination programs, optimize HPV-related cancer screening programs, and enhance public health initiatives for the prevention and early detection of non-cervical HPV-related cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.