Evidence map›Paper›PMID 42011536›Full record

ArticleJournal of the American Chemical Society2026

Circularity in Sequence-Controlled Copolyamides Enabled by Regioselective Enzymatic Hydrolysis.

Isaiah T Dishner, Célestin Bourgery, Dana L Carper, Connor J Cooper, John F Cahill, Jai M Mehta, Sergey Yakubov, Hong-Hai Zhang, Nduka D Ogbonna, Joshua T Damron and 5 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Isaiah T DishnerChemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0002-7333-9182
Célestin BourgeryBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Dana L CarperBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Connor J CooperIndependent Researcher, Candia, New Hampshire 03034, United States.
John F CahillBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0002-9866-4010
Jai M MehtaDepartment of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, Tennessee 37996, United States.ORCID 0009-0000-2824-2640
Sergey YakubovComputer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Hong-Hai ZhangCenter for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0003-1413-8847
Nduka D OgbonnaChemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0001-9383-6023
Joshua T DamronChemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0003-3409-0190
Robert L SacciChemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0002-0073-5221
Vera BocharovaChemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0003-4270-3866
Jerry M ParksBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0002-3103-9333
Joshua K MichenerBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0003-2302-8180
Jeffrey C FosterChemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID 0000-0002-9097-8680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequence-controlled polymers enable precise control over macromolecular structures and function, but both their synthesis and end-of-life management remain fundamental challenges. Achieving high sequence fidelity is synthetically demanding, and conventional depolymerization methods lack regioselectivity, leading to irreversible loss of encoded molecular information and limiting polymer circularity. Enzymatic catalysis offers a potential solution by combining substrate specificity with selective bond cleavage. Here, we report the synthesis, characterization, and regioselective enzymatic depolymerization of

Indexed as

HydrolasesNylonsHydrolysisStereoisomerismHydrolasesNylons

Identifiers

PMID42011536
PMCPMC13154176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.