ArticleLab on a chip2026
Region-specific proteomic profiling of brain interstitial fluid
Article in Lab on a chip, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- An opto-microperfusion neural probe for multiplexed detection of optogenetically evoked neurochemical release dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Interstitial fluid (ISF) within the brain parenchyma contains secreted factors related to brain function, metabolism, and neurodegenerative disorders. Cerebrospinal fluid (CSF) is commonly sampled due to its accessibility in well-defined spaces, but it does not fully capture the diversity of the brain secreted proteome. The brain is remarkably heterogeneous on a millimeter scale or smaller, and the secreted proteome likely reflects that heterogeneity. Traditional methods like cerebral microdialysis suffer from recovery loss and tissue damage due to semipermeable membranes and large probe sizes. This study develops a micro-invasive, membrane-free platform for ISF sampling, enabling mass spectrometry analysis of small sample volumes with high spatial resolution and minimal tissue damage. Also, this platform collects samples within approximately 15 minutes, representing a major reduction in sampling time compared to microdialysis. We analyzed proteomic profiles of ISF from the nucleus accumbens and substantia nigra, revealing significant differences in protein abundance and composition indicative of their biological functions. We also compared ISF with CSF and found significantly more proteins associated with brain-specific functions, such as synaptic transmission and vesicle-mediated transport. This novel ISF sampling method can enhance clinical liquid biopsy techniques for brain diseases and provides insights into distinct molecular profiles of different brain regions.
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Registered trials
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