ArticleJournal of hepatocellular carcinoma2026
High-Volume Dilution of Drug-Eluting Beads Reduces Severe Pain After DEB-TACE: A Single-Center Retrospective Study.
Article in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Abdominal pain is the most frequent consequence of postembolization syndrome (PES) after drug-eluting bead transarterial chemoembolization (DEB-TACE). The analgesic impact of an easily modifiable intraprocedural factor-microsphere suspension dilution, remains unclear. We evaluated whether high-fold dilution during DEB-TACE reduces early postprocedural pain and severe pain risk without compromising short-term response and safety. Methods: This single-center retrospective cohort study included 362 patients with hepatocellular carcinoma who underwent DEB-TACE. The patients were divided into conventional dilution (Group A, n = 103), 30-50-fold dilution (Group B, n = 127), and > 50-fold dilution (Group C, n = 132). The outcomes included a maximum visual analog scale (VAS) pain score within 72 hours and moderate-to-severe (VAS score ≥ 4) and severe (VAS score ≥ 7) pain scores. Associations were tested through Spearman correlation and trend tests. Univariable and multivariable logistic regression were used to estimate adjusted odds ratios (ORs) for severe pain. Short-term tumor response was also assessed according to mRECIST at 1-3 months after the index procedure. Results: The maximum 72-hour VAS score decreased with increasing dilution (median [interquartile range]: 6.0 [4.0-10.0] vs. 4.0 [2.0-5.0] vs. 0.0 [0.0-4.0]; Conclusion: High-fold microsphere suspension dilution during DEB-TACE was associated with reduced early postprocedural abdominal pain without compromising short-term laboratory safety.
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