Evidence map›Paper›PMID 42011404›Full record

ArticleiScience2026

Hemispheric asymmetry in depressive symptoms is associated with sex-divergent functional brain connectivity patterns.

Shuqi Jia, Weizhi Liu, Qun Zhao, Somang Yun, Xin Xin, Cong Liu, Shufan Li, Peng Wang, Zhaosong Yin, Wei Guan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuqi JiaSchool of Athletic Performance, Shanghai University of Sport, Shanghai, China.
Weizhi LiuPTSD Prevention Laboratory, Department of Psychology, Department of Basic Psychology, Naval Medical University, Shanghai, China.
Qun ZhaoSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Somang YunSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Xin XinSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Cong LiuSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Shufan LiSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Peng WangSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Zhaosong YinSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Wei GuanSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Fen YuSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Qing LiuSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Zhaohui GuoSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Xi WangSchool of Physical Education, Shanghai University of Sport, Shanghai, China.
Xing WangSchool of Physical Education, Shanghai University of Sport, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemispheric asymmetry has been linked to depressive symptoms, yet its relationship with large-scale brain network organization remains unclear. Resting-state electroencephalography (EEG) was recorded from 489 university students to examine hemispheric asymmetry associated with depressive symptoms and its relation to functional connectivity, with attention to sex-dependent patterns. Asymmetry indices and connectivity strength and density were computed across six frequency bands. Depressive symptoms were primarily associated with asymmetry alterations in the α and δ bands, most prominently in frontal α1 asymmetry. At the network level, elevated depressive symptoms were linked to reduced connectivity strength and density, particularly in the α2 and β1 bands, with significant sex × depressive symptom interactions. Alpha2-band connectivity statistically explained a proportion of the association between depressive symptoms and multiple asymmetry indices. These findings indicate that hemispheric asymmetry co-occurs with frequency- and sex-dependent variations in large-scale functional brain organization.

Indexed as

behavioral neurosciencecognitive neuroscienceneuroscience

Identifiers

PMID42011404
PMCPMC13092069

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.