Evidence map›Paper›PMID 42011354›Full record

ArticleAvicenna journal of phytomedicine

Suppressive effect of lemon (

Wira Eka Putra, Chalissa Nuruzzulfa, Dea Esaayu Mahabella, Ramdhani Faradilla Intania Nuraıda, Arief Hıdayatullah, Muhaimin Rifa'i

Abstract read
In one paragraph

Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wira Eka PutraBiotechnology Study Program, Department of Applied Sciences, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Indonesia.
Chalissa NuruzzulfaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia.
Dea Esaayu MahabellaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia.
Ramdhani Faradilla Intania NuraıdaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia.
Arief HıdayatullahDemocratic Governance and Poverty Reduction Unit, United Nations Development Programme, Eijkman-RSCM Building, Jakarta, Indonesia.
Muhaimin Rifa'iDepartment of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Cancer is a worldwide health issue which recognized as a chronic condition resulting from the unregulated growth of abnormal cells. Breast cancer has overtaken lung cancer as the most often diagnosed malignancy among all genders, with a projected three million new cases by 2040. Many treatment options are available, however, latest therapies are associated with undesirable side effects. Materials and Methods: The treatment group consisted of four subgroups: a vehicle control group, a DMBA induction group, a CLE 50 group, and a CLE 200 group. Flow cytometry was used to assess the proportions of the following cell populations: Gr-1 Results: In this study, we discovered that CLE reduces the number of immune system profiles to normal levels, including granulocytes, macrophages, natural killer cells, and effector T cells, while increasing the population of regulator T cells to normal levels. Moreover, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) evaluation showed that several significant CLE compounds meet the drug-like requirements. Conclusion: This research revealed that CLE might be developed as a supplemental or additional cancer treatment.

Indexed as

Adaptive immunityCancerCitrus limonImmunomodulatoryInnate immunity

Identifiers

PMID42011354
PMCPMC13092160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.