ArticleAvicenna journal of phytomedicine
Dexamethasone-induced hepatic biochemical and pathological damages are attenuated by
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The protective effects of ethanolic extract of Materials and Methods: Following GC-MS phytochemical analyses of the extract, Results: Findings revealed that CD extract does have concentration-dependent free radical-scavenging activity, and it possesses phenols and flavonoids contents. The most abundant compound of the CD extract was n-hexadecanoic acid. The DEX-induced hepatic functional enzymes and lactate dehydrogenase levels were significantly (p<0.05) reduced in both models. Moreover, the DEX-induced oxidative stress was improved by CD extract (45%). The DEX-elevated blood glucose (20%) and triglycerides (60%) were reduced in CD-treated animals. The DEX-generated hepatic macrovesicles and lipid droplets in HepG2 cells were reduced. Conclusion: These results suggest that CD extract could be an effective compound for protection from DEX-induced hepatic injuries.
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