ArticleAmerican journal of ophthalmology case reports2026
Toxoplasmic granuloma within an epiretinal membrane in a patient with recurrent ocular toxoplasmosis.
Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To report the occurrence and pathological confirmation of a granuloma within an epiretinal membrane (ERM) with Case description: A 54-year-old female patient presented to ophthalmic consultation with decreased visual acuity (VA) and myodesopsia in the right eye (OD). She reported a history of recurrent ocular toxoplasmosis in the OD, treated with sequential courses of oral Folate synthesis inhibitors and anti-inflammatory therapy. Best corrected VA (BCVA) at initial examination was 20/400 in OD and 20/20 in OS. Fundus examination in OD revealed multiple white retinal lesions, superior to the superior temporal vessels, and temporal to the macula. OCT of the macular area showed cystoid macular edema and a thick ERM. The patient was initiated on TMP-SMX (160 mg/800 mg/day), azithromycin (250 mg/day), meprednisone (40 mg/day) and folinic acid. The BCVA improved to 20/40 after 45 days of treatment. Following initial treatment suspension, the BCVA decreased to 20/60. Given the extent of retinal fibrosis and architectural disruption of the retina by ERMs a vitrectomy was scheduled. ERMs were successfully peeled, and silicone tamponade was performed. Pathology results revealed the presence of a granuloma within the ERM. Immunohistochemistry confirmed the presence of Conclusion: The presence of
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