ArticleHealth science reports2026
Oral Health Status of Children and Adolescents With Phenylketonuria: A Case-Control Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Phenylketonuria (PKU) is a genetic metabolic disorder affecting phenylalanine metabolism. While its neurological and skeletal impacts are well-documented, its influence on oral health is less understood. This study aimed to evaluate the oral health status of children and adolescents with PKU compared to healthy controls. Methods: The case-control study included 136 children and adolescents aged 6-18 years, with 68 PKU patients and 68 healthy controls from February to June 2024. Oral hygiene practice was assessed from both groups. Oral health was assessed using the ICDAS, gingival index (GI), and basic periodontal examination (BPE) indices. Sweet nutrition consumption was also analyzed, and the relationship between serum phenylalanine (Phe) levels and oral health indices was examined. Results: Assessment of oral hygiene showed poorer oral hygiene in PKU patients, with 54.4% brushing less than once daily compared to 26.5% of controls ( Conclusion: The findings underscore the importance of preventive oral care for PKU patients. A multidisciplinary approach involving dentists from the time of diagnosis of disease is recommended to ensure comprehensive dental and periodontal care, schedule regular appointments, and implementation of preventive strategies.
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