Evidence map›Paper›PMID 42011262›Full record

ReviewInternational journal of pharmaceutics: X2026

The self-assembly mechanisms of glycyrrhizic acid: Permeation enhancement and transdermal applications.

Lin Zhou, Youran Deng, Mingjie Ou, Zhuxian Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lin ZhouDermatology Hospital, Southern Medical University, Guangzhou 510091, China.
Youran DengSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Mingjie OuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Zhuxian WangDermatology Hospital, Southern Medical University, Guangzhou 510091, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycyrrhizic acid (GA) is an amphiphilic triterpenoid saponin compound derived from licorice. This review first summarizes the behaviors and evolution mechanisms of GA forming different nanostructures (dimers, micelles, nanoparticles, nanofibers, and hydrogels) under varying conditions (concentration, temperature, pH, ionic strength) and intermolecular forces. Subsequently, it introduces the transdermal permeation enhancement and bioavailability improvement of hydrophobic drugs when encapsulated by GA. GA significantly enhances drug solubility and stability, promotes drug penetration, and improves targeted delivery efficiency, thereby increasing transdermal bioavailability. Finally, the functions of GA in transdermal drug delivery and its penetration enhancement mechanism are elucidated. It primarily enhances permeation by altering the arrangement of stratum corneum (SC) lipids and keratin, ultimately weakening the skin barrier. This review reveals principles dominating the self-assembly and permeation enhancement of GA, providing a paradigm for the self-assembly of other natural products and offering references for further applications of GA in transdermal drug delivery.

Indexed as

BioavailabilityGlycyrrhizic acidPermeation enhancementSelf-assemblyTransdermal drug delivery

Identifiers

PMID42011262
PMCPMC13092070

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.