Evidence map›Paper›PMID 42011261›Full record

ArticleInternational journal of pharmaceutics: X2026

Solvent-free aqueous spray drying of poorly soluble drugs enabled by hot-feed micellar solubilization and high-Tg polymer matrices.

Wenling Zheng, Hui Chen, Rongrong Xue, Ziqing Wu, Yongming Liu, Fenghua Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenling ZhengSchool of Resources and Chemical Engineering, Sanming University, Sanming, Fujian 365004, PR China.
Hui ChenSchool of Resources and Chemical Engineering, Sanming University, Sanming, Fujian 365004, PR China.
Rongrong XueSchool of Resources and Chemical Engineering, Sanming University, Sanming, Fujian 365004, PR China.
Ziqing WuSchool of Education and Music, Sanming University, Sanming, Fujian 365004, PR China.
Yongming LiuSchool of Education and Music, Sanming University, Sanming, Fujian 365004, PR China.
Fenghua ChenSchool of Resources and Chemical Engineering, Sanming University, Sanming, Fujian 365004, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poor aqueous solubility limits the oral bioavailability of many BCS II drugs, while conventional spray drying of amorphous solid dispersions (ASDs) often relies on organic solvents. Here we develop an aqueous spray-drying (AQSD) strategy that couples temperature-boosted solubility with poloxamer-enabled micellar solubilization and a high-Tg polymer matrix. Using celecoxib (CEL) as a model drug, heating increased intrinsic solubility and poloxamer 407 (P407) further raised apparent solubility to a ≥ 1 mg·mL

Indexed as

Amorphous solid dispersionAqueous spray dryingHigh-Tg polymerMicellar solubilizationPoloxamer 407

Identifiers

PMID42011261
PMCPMC13092062

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.