Evidence map›Paper›PMID 42011200›Full record

ReviewBioactive materials2026

Topographical design principles for osteochondral tissue engineering.

Lucia Aboal-Castro, Vasiliki K Kolliopoulos, Carmen Alvarez-Lorenzo, Antonios G Mikos, Luis Diaz-Gomez

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucia Aboal-CastroI+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Materials (iMATUS), and Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Vasiliki K KolliopoulosDepartment of Bioengineering, Rice University, Houston, TX, 77030, USA.
Carmen Alvarez-LorenzoI+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Materials (iMATUS), and Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Antonios G MikosDepartment of Bioengineering, Rice University, Houston, TX, 77030, USA.
Luis Diaz-GomezI+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Materials (iMATUS), and Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The osteochondral unit has a complex hierarchical structure where cartilage and subchondral bone show different physical, chemical, and functional properties. Replicating this structure remains a major challenge in osteochondral tissue engineering. Among various scaffold design factors, surface topography has emerged as a powerful regulator of cell behavior, but its rational integration into osteochondral constructs is still limited. This review systematically explores how topographical features affect cartilage and bone regeneration, focusing especially on feature size and anisotropy. Evidence across

Indexed as

Bioactive scaffoldBoneCartilageOsteochondral repairTopography

Identifiers

PMID42011200
PMCPMC13091945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.