ArticleAdvances in ophthalmology practice and research
Swept-source OCTA assessment of iris vasculature as a biomarker for myopic macular degeneration severity.
Article in Advances in ophthalmology practice and research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To investigate the vessel area density (VAD) and morphological features of the iris in patients at different stages of myopic macular degeneration (MMD) using swept-source optical coherence tomography angiography (SS-OCTA). Methods: In this retrospective case-control study, 106 eyes of 106 high myopia patients (axial length (AL) ≥26 mm) were included and classified into different MMD categories according to the International META-PM Classification. The VAD of iris, iris volume (IV), area of anterior iris surface (IS), area of posterior IS, and average iris thickness (IT) were evaluated using SS-OCTA. Associations among iris vasculature, iris morphology, and MMD categories were investigated. Results: Full-range, inner-region, and intermediate-region VAD of the iris decreased significantly with increasing MMD severity (all Conclusions: Iris blood flow, quantified by VAD, decreased with increasing MMD severity. Iris VAD may represent a promising candidate biomarker for non-invasive monitoring of MMD severity. Additionally, the association between VAD and AL or iris morphology varied across MMD categories.
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