ArticleAndrology2026
Computer-Assisted Sperm Analysis (CASA) Versus Manual Evaluation and the Clinical Significance of Sperm Hyperactivated Motility.
Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSemen analysis remains the first-line diagnostic test for male infertility, although it is affected by operator subjectivity. Computer-assisted sperm analysis (CASA) is proposed to improve objectivity; however, its accuracy and clinical relevance remain uncertain.
objectivesWe evaluated 424 samples from men attending routine semen analysis and 179 samples from male partners of ICSI couples to compare manual assessment with a CASA system (Ceros II), and to explore whether CASA-derived kinematic parameters, in particular hyperactivated motility (HA), predict ICSI outcomes. MATERIALS AND
methodsManual (according to WHO manual) and CASA assessments were compared using correlation analysis, Passing-Bablok regression, and Bland-Altman plots; kinematic parameters were evaluated in relation to ICSI outcomes.
resultsSignificant correlations were found between CASA and manual assessment for rapid progressive motility and for sperm count for samples with less than 50 × 10 DISCUSSION: These findings suggest that CASA provides objective, reproducible assessment of sperm motility, and that hyperactivated motility may serve as a clinically relevant marker to improve prediction of ICSI outcomes.
conclusionsCASA may provide useful support for routine semen analysis and identify clinically meaningful kinematic parameters.
trial registrationNot applicable.
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