ArticleKorean journal of orthodontics2026
Effectiveness of acetaminophen in comparison with ibuprofen for pain control in orthodontic patients: A systematic review and meta-analysis.
Article in Korean journal of orthodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
7 authors.
Funding
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Abstract
Objective: To compare the effectiveness of acetaminophen and ibuprofen for pain control in orthodontic patients. Methods: Using the PICO strategy, studies were included without restrictions on publication date or language. PubMed, EMBASE, Scopus, Virtual Health Library (VHL)/Latin American and Caribbean Health Sciences Literature (LILACS), Web of Science, and Cochrane Library databases were searched, along with gray literature, up to July 2025. The methodological quality of the studies was assessed using the Cochrane Risk of Bias 2 tool. A meta-analysis was conducted using R software. Subgroup and leave-one-out sensitivity analyses were conducted for moderate or high heterogeneity. Results: Of the 1,139 studies identified, 13 were included. The ages of the participants ranged from 9 to 30 years. Most studies (n = 7) were double-blinded. Tooth movement was induced by fixed appliances or separators, and two studies had a high risk of bias. Pain control with the two medications showed no significant differences at rest at 24 and 48 hours or during chewing at 6, 24, and 48 hours ( Conclusions: Pain control during orthodontic tooth movement did not differ between the two medications.
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