Evidence map›Paper›PMID 42010896›Full record

ArticleThe New phytologist2026

Light regulates capsaicinoid biosynthesis via the CaHY5-CaBBX2-CaACS8 module in pepper.

Youxin Yang, Dan Wu, Jiaxin Liu, Ying Luo, Feng Yang, Huiling Zhu, Feng Wang, Ting Yu, Xiaobin Wang, Jinyin Chen and 2 more

Abstract read
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Lighting up the pepper heat.The New phytologist · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Youxin YangJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.ORCID https://orcid.org/0000-0001-8078-5677
Dan WuJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.
Jiaxin LiuJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.
Ying LuoJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.
Feng YangResearch Center of Plant Functional Genes and Tissue Culture Technology, College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.ORCID https://orcid.org/0000-0001-5351-1531
Huiling ZhuJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.
Feng WangCollege of Horticulture, Shenyang Agricultural University, Shenyang, 110866, Liaoning, China.
Ting YuJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.ORCID https://orcid.org/0000-0001-6571-6542
Xiaobin WangJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.ORCID https://orcid.org/0000-0003-1695-5998
Jinyin ChenJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.
Huibin HanResearch Center of Plant Functional Genes and Tissue Culture Technology, College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.ORCID https://orcid.org/0000-0002-8758-4752
Yong ZhouJiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.ORCID https://orcid.org/0000-0002-8432-6678

Funding

Ganpo Talents Support Program of Jiangxi Province, China gpyc20240199Natural Science Foundation of Jiangxi Province, China 20223BBF61017the National Natural Science Foundation of China 32160739the National Natural Science Foundation of China 32372797the National Natural Science Foundation of China 32460797The Outstanding Youth Fund Project of the Natural Science Foundation of Jiangxi Province, China 20212ACB215006
6 · The paper itself

Abstract

Capsaicinoids are a class of unique alkaloids that confer the pungent taste to pepper fruits. However, it remains largely unknown how light regulates the biosynthesis of capsaicinoids. We conducted a metabolic analysis on light- and dark-adapted pepper fruits. The results showed that dark-adapted pepper fruits had lower capsaicinoid contents and correspondingly downregulated transcription of capsaicinoid biosynthetic genes (CBGs), indicating that light plays a crucial role in capsaicinoid biosynthesis. Furthermore, silencing of CaHY5, a pivotal transcription factor gene in the light signaling pathway, decreased the content of capsaicinoid and suppressed the expression of CBGs, whereas transient overexpression of CaHY5 generated exactly opposite results. CaHY5 can bind to the G-box motif in the promoters of CaBBX2 and CaACS8, thereby enhancing their transcriptional levels. The activated CaBBX2 then binds to the T/G-box in the CaACS8 promoter to stimulate its expression. CaBBX2 or CaACS8 silencing led to decreased levels of capsaicinoids, while their transient overexpression produced increased capsaicinoid contents. Collectively, our results indicated that the light-activated CaHY5-CaBBX2-CaACS8 regulatory module plays a pivotal role in capsaicinoid biosynthesis. These findings provide new insights into the influence of light on capsaicinoid biosynthesis and potential targets for activation of this biosynthetic pathway in pepper.

Indexed as

CapsaicinCapsicumLightPlant ProteinsTranscription FactorsBiosynthetic PathwaysFruitGene Expression Regulation, PlantGene SilencingGenes, PlantPromoter Regions, GeneticProtein BindingCapsaicinPlant ProteinsTranscription Factorscapsaicinoid biosynthesisHY5lightpepperregulatory module

Identifiers

PMID42010896
PMCPMC13539973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.