ArticleChemistryOpen2026
Sustainable Ethanol-Based Reversed-Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics.
Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study presents a sustainable chromatographic method for the analysis of diltiazem. Retention behavior and the effect of mobile phase pH were investigated to determine the dissociation constant. Chromatographic experiments were performed at 37°C on a Gemini NX C18 column in binary mixtures of ethanol-water containing 40%, 45%, and 50% (v/v) ethanol and methanol-water containing 45%, 50%, and 55% (v/v) methanol. Using these retention data, the
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