Evidence map›Paper›PMID 42010754›Full record

SynthesisInternational journal of dental hygiene2026

The Impact of Periodontal Health Interventions on the Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis.

Jorge Moldes, Joao Botelho, Manuel Rodríguez-Yáñez, Vanessa Machado, Juan Blanco, Tomás Sobrino, Rogelio Leira, Yago Leira

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of dental hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jorge MoldesFamily and Community Medicine Department, Bueu Health Centre, Pontevedra University Clinical Hospital, Pontevedra, Spain.ORCID https://orcid.org/0009-0008-5939-9876
Joao BotelhoPeriodontology Department and Evidence-Based Hub, Clinical Research Unit, Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz and Cooperative de Ensino Superior, Caparica, Portugal.ORCID https://orcid.org/0000-0002-1019-8263
Manuel Rodríguez-YáñezNeurology Department, University Clinical Hospital, Santiago de Compostela, Spain.
Vanessa MachadoPeriodontology Department and Evidence-Based Hub, Clinical Research Unit, Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz and Cooperative de Ensino Superior, Caparica, Portugal.
Juan BlancoPeriodontology Unit, Faculty of Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Tomás SobrinoNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, Madrid, Spain.ORCID https://orcid.org/0000-0002-9760-8690
Rogelio LeiraNeurology Department, University Clinical Hospital, Santiago de Compostela, Spain.
Yago LeiraPeriodontology Unit, Faculty of Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0001-5027-7276

Funding

Instituto de Salud Carlos III CP23/00071Xunta de Galicia IN607D2024/003
6 · The paper itself

Abstract

aimTo systematically review the evidence on the relationship between periodontal health interventions and the risk of first-ever ischemic stroke. MATERIALS AND

methodsSearch strategy included electronic and hand searching to January 2025. MEDLINE (OVID), EMBASE (OVID), SCOPUS, LILACS, Web of Science (WOS) and Cochrane Central Register of Controlled Trials (CENTRAL) were searched. Eligible studies included clinical trials and observational designs reporting on any periodontal health intervention and ischemic stroke. Screening and data extraction were performed independently and in duplicate. Meta-analyses were conducted when appropriate.

resultsSeven studies involving 1,886,947 participants met the inclusion criteria from an initial set of 634 records. In a random-effects meta-analysis, periodontal interventions were associated with a lower risk of ischemic stroke (HR: 0.88 [0.81-0.95]). Tooth scaling, in particular, was associated with a reduced risk (HR: 0.84 [0.76-0.92]).

conclusionPeriodontal health interventions-especially tooth scaling-appear to be associated with a lower risk of ischemic stroke. These findings suggest a potential role for periodontal care in stroke prevention.

trial registrationPROSPERO number: CRD42023450471.

Indexed as

Ischemic StrokePeriodontal DiseasesDental ScalingHumansRisk Factorscerebrovascular disordersdental caredental scalingischemic strokeperiodontitis

Identifiers

PMID42010754
PMCPMC13622914

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.