ArticleVirology journal2026
Detection of JC virus DNA in CSF of pediatric patients with non-PML neurological disorders.
Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- First Report of Fatal Disseminated Blastomyces percursus Infection in a Liver Transplant Recipient in Iran, a Non-endemic Country: A Case Report.Mycopathologia · 2026Article
- Development of VP1 based indirect ELISAs for BK and JC polyomaviruses with seroprevalence assessment and cross reactivity evaluation.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundJC virus (JCV) is a human polyomavirus classically associated with progressive multifocal leukoencephalopathy (PML). Its role in other central nervous system (CNS) disorders - and the contribution of related polyomaviruses such as BK virus (BKV) and simian virus 40 (SV40) - remains poorly defined in pediatric populations, especially among immunocompromised patients.
methodsWe analysed 64 cerebrospinal fluid (CSF) specimens collected from children evaluated for suspected viral encephalitis or meningoencephalitis between March and October 2024. Broad-range and virus-specific PCR assays targeting conserved regions of the large T antigen (LT-ag) and VP1 genes were performed. Positive amplicons were confirmed by bidirectional Sanger sequencing and phylogenetic analysis. Associations with HIV status were assessed using chi-square tests.
resultsJCV DNA was detected in 4 of 64 samples (4/64; 6.3%), BKV DNA in 5 of 64 samples (5/64; 7.8%), and both viruses were co-detected in 3 samples (3/64; 4.7%). All positive detections occurred in HIV-positive patients (JCV: 4/19 HIV+; BKV: 5/19 HIV+), yielding statistically significant associations with HIV status (JCV p = 0.006; BKV p = 0.002). No SV40 DNA was identified. Phylogenetic reconstruction grouped patient sequences tightly with reference JCV and BKV strains, supporting authentic detection rather than laboratory contamination.
conclusionsThese results provide molecular evidence that JCV and BKV can be detected in the CSF of pediatric patients with suspected CNS infection - predominantly in the setting of HIV-associated immunosuppression - and may represent underrecognized contributors to non-PML neurological disease. Larger, longitudinal studies integrating clinical, radiological and quantitative viral-load data are required to define causality and clinical impact.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.