Evidence map›Paper›PMID 42010614›Full record

ReviewBMC biology2026

Physiological implications of phase separation in vesicle organization and trafficking.

Che Liu, Jinbo Cheng, Xiandeng Wu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Che Liu *Department of Neuroscience, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.
Jinbo Cheng *Department of Neuroscience, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.
Xiandeng WuDepartment of Neuroscience, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China. wuxd3@sustech.edu.cn.

Funding

National Natural Science Foundation of China 32494762Shenzhen Medical Research Fund E250200110, E250200111
6 · The paper itself

Abstract

Phase separation has emerged as a key mechanism of cellular compartmentalization, complementing classical membrane-bound organelles. In addition to forming membraneless compartments that provide confined environments for biochemical reactions, phase separation actively organizes and regulates membrane vesicles. Protein condensates interact with vesicular organelles through defined modes of communication, influencing their assembly, trafficking, and turnover. This review highlights recent advances in understanding how phase separation contributes to vesicle biology, including synaptic vesicle cycling, COPII-mediated transport, and endocytic vesicle organization, processes essential for maintaining physiological homeostasis and efficient intracellular transport.

Indexed as

COP-Coated VesiclesPhase SeparationTransport VesiclesAnimalsBiological TransportHumansOrganellesMembraneless condensatesMembranous organellesPhase separationVesicle trafficking

Identifiers

PMID42010614
PMCPMC13231674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.