Evidence map›Paper›PMID 42010596›Full record

ArticleJournal of nanobiotechnology2026

A modular protein-nucleic acid nanodevice for non-genetic engineering of mesenchymal stem cells to target pathological collagen in liver fibrosis.

Fengyu Tian, Kai Wang, Chunbing Zheng, Xi Liu, Peng Shi, Zeyuan Wang, Tianyi Zhang, Bing Chen, Fen Wang, Honghui Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fengyu Tian *State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Kai Wang *State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Chunbing ZhengYuanpin Cell Biotechnology Group Co., Ltd, Changsha, 410100, Hunan, China.
Xi LiuSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China.
Peng ShiSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China.
Zeyuan WangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Tianyi ZhangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Bing ChenDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, 410082, China.
Fen WangDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, 410082, China. wfen-judy@csu.edu.cn.
Honghui WangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Zhou NieState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Yan HuangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. yanhuang@hnu.edu.cn.

Funding

Key Research and Development Program of Hunan Province of China 2024JK2137National Natural Science Foundation of China 22274041, 22422404 and 22374036Natural Science Foundation of Hunan Province 2023ZJ1120
6 · The paper itself

Abstract

Mesenchymal stem cell (MSC) therapies hold immense promise for regenerative medicine, yet their clinical translation is hindered by inefficient delivery and poor homing at injury sites. Here, we exploited a modular protein-nucleic acid nanodevice for non-genetic engineering of MSCs, which enables the cells to dock onto pathological collagen-rich tissues. The protein-nucleic acid nanodevice integrates two key modules: a multi-functional fusion protein for collagen binding and clickable covalent conjugation between protein and DNA, and a MSC-specific binding DNA nanostructure. Benefiting from the modularity of the nanodevice, the functional modules were optimized to address the challenges for keeping the stemness of MSCs and efficient homing of them to the fibrotic environment. Here collagen-binding domain (CBD) was a peptide with higher affinity to collagen I (CBD

Indexed as

CollagenDNA NanostructuresLiver CirrhosisMesenchymal Stem CellsAnimalsAptamers, NucleotideCell DifferentiationHumansMaleMiceAptamers, NucleotideCollagenCollagenMesenchymal stem cellsNon-genetic surface engineeringProtein-nucleic acid nanodeviceTargeted delivery

Identifiers

PMID42010596
PMCPMC13227788

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.