Evidence map›Paper›PMID 42010463›Full record

ArticleBMC genomic data2026

Complete genome sequence of Streptococcus periodonticum strain CRC221 isolated from human colorectal tumor tissue.

Jia-Su Li, Shu-Dan Chen, Jia-Quan Wu, Min-Xin Gao, Zhao-Shen Li, Yi-Qi Du, Wei-Liang Hou

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In one paragraph

Article in BMC genomic data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jia-Su Li *Department of Gastroenterology, National Key Laboratory of Immunity and Inflammation, Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.ORCID 0000-0001-8805-5636
Shu-Dan Chen *School of Basic Medical Sciences, Naval Medical University, Shanghai, 200433, China.
Jia-Quan Wu *School of Basic Medical Sciences, Naval Medical University, Shanghai, 200433, China.
Min-Xin GaoDepartment of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Zhao-Shen LiDepartment of Gastroenterology, National Key Laboratory of Immunity and Inflammation, Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. zhs.li@hotmail.com.
Yi-Qi DuDepartment of Gastroenterology, National Key Laboratory of Immunity and Inflammation, Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. duyiqi@hotmail.com.
Wei-Liang HouDepartment of Gastroenterology, National Key Laboratory of Immunity and Inflammation, Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. houweiliang@tongji.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesStreptococcus periodonticum is a facultative anaerobic, Gram-positive coccus originally isolated from human periodontitis lesions and implicated in colorectal cancer pathogenesis. This study aimed to comprehensively characterize the genome of strain CRC221, isolated from human colorectal tumor tissue, to support future research on its potential role in tumorigenesis. DATA DESCRIPTION: Genomic DNA from strain CRC221 was sequenced using Illumina NovaSeq 6000 and PacBio platforms. The final assembly yielded a complete circular chromosome of 1,851,769 bp with 38.81% GC content. Structural annotation predicted 1,837 genes, comprising 1,707 protein-coding sequences (CDSs), 12 rRNAs, 59 tRNAs, 3 non-coding RNAs, and 56 pseudogenes. Functional annotation associated most CDSs with core bacterial survival pathways, particularly carbohydrate and amino acid metabolism. Notably, 94 genes were annotated as virulence factors, 68 as antibiotic resistance genes, and 319 as pathogen-host interaction factors. Comparative genomics revealed an ANI of 97.51% and a dDDH value of 71.8% against the reference S. periodonticum genome (GCA_003963555.1). Pan-genome analysis indicated an open genome architecture containing 199 conserved core genes. These genomic data provide a foundation for investigating the biological characteristics of intratumoral S. periodonticum and its potential relevance to colorectal cancer.

Indexed as

Colorectal NeoplasmsGenome, BacterialStreptococcusBase CompositionHumansVirulence FactorsWhole Genome SequencingVirulence FactorsColorectal cancerComplete genome sequenceIntratumoral microbiotaStreptococcus periodonticum

Identifiers

PMID42010463
PMCPMC13231736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.