ArticleAlzheimer's research & therapy2026
VR-based path integration predicts individual risk of rapid cortical decline: a one-year longitudinal study in cognitively unimpaired adults.
Article in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPath integration (PI) is a navigational computation that can be affected by aging and Alzheimer’s disease (AD). Virtual-reality PI (VR-PI) preferentially engages medial temporal circuits and can reveal subtle changes that occur prior to overt impairment. Nevertheless, the longitudinal association between PI performance and structural brain changes remains unclear.
methodsIn a 1-year longitudinal cohort of 71 cognitively unimpaired adults, we assessed baseline VR-PI performance (PI error and angular error), AD-related plasma biomarkers (p-tau181 and glial fibrillary acidic protein [GFAP]), and longitudinal cortical thickness and volume from MRI scans acquired one year apart, to examine whether baseline PI performance was associated with both plasma biomarkers and subsequent structural brain changes. Linear mixed-effects (LME) models were used to assess whether baseline PI performance predicted time-dependent regional thinning and atrophy.
resultsGreater baseline PI error was associated with greater longitudinal cortical thinning and volume decline in the parahippocampal gyrus, middle temporal gyrus, posterior cingulate cortex, and caudal middle frontal gyrus. Similar spatial patterns were observed for angular error, indicating consistent associations across PI measures. Sensitivity analyses using extended models that additionally included either APOE ε4 status or the baseline age × time interaction, as well as analyses restricted to participants aged ≥ 40 years, did not materially alter the pattern of results. Both baseline PI error and angular error were associated with plasma p-tau181 (r = 0.38 for both, 95% confidence interval [CI]: 0.16–0.56), and PI error was associated with GFAP levels (r = 0.36, 95% CI: 0.14–0.55). Receiver operating characteristic (ROC) curve analyses showed that baseline PI error best discriminated individuals with accelerated parahippocampal thinning (10% threshold; cross-validated AUC = 0.87).
conclusionsBaseline VR-PI performance was associated with longitudinal cortical thinning and volume decline in AD-vulnerable regions, along with additional associations with plasma p-tau181 and GFAP levels. VR-PI performance may reflect both molecular (blood biomarker) and structural (MRI) signatures preceding overt clinical impairment.
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