Evidence map›Paper›PMID 42010249›Full record

ArticleNature communications2026

Igh nuclear speckle association promotes V(D)J recombination.

Saurabh Priyadarshi, Khalid H Bhat, Ellen B Drake, Sarah Naiyer, Hammad Farooq, Xinyan Qu, Jose F Cantillo, Xue Lei, Ebru Ermis, Eden Kleiman and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Saurabh PriyadarshiDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA.ORCID http://orcid.org/0000-0003-1350-717X
Khalid H BhatDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA.ORCID http://orcid.org/0000-0002-0952-7496
Ellen B DrakeDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA.ORCID http://orcid.org/0000-0002-2490-7366
Sarah NaiyerDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA.ORCID http://orcid.org/0000-0002-3961-5489
Hammad FarooqCenter for Bioinformatics and Quantitative Biology, and Department of Biomedical Engineering, University of Illinois Colleges of Engineering and Medicine, Chicago, IL, 60612-7344, US.ORCID http://orcid.org/0000-0001-5691-298X
Xinyan QuDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA.
Jose F CantilloDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA.
Xue LeiCenter for Bioinformatics and Quantitative Biology, and Department of Biomedical Engineering, University of Illinois Colleges of Engineering and Medicine, Chicago, IL, 60612-7344, US.ORCID http://orcid.org/0000-0001-9647-3782
Ebru ErmisDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.
Eden KleimanDepartment of Immunology and Microbiology, Scripps Research, La Jolla, CA, 92037, USA.
Sajad A BhatDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA.
Andrew KohDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USA.ORCID http://orcid.org/0000-0002-4198-0143
Jie LiangCenter for Bioinformatics and Quantitative Biology, and Department of Biomedical Engineering, University of Illinois Colleges of Engineering and Medicine, Chicago, IL, 60612-7344, US.ORCID http://orcid.org/0000-0002-2773-6427
Ann J FeeneyDepartment of Immunology and Microbiology, Scripps Research, La Jolla, CA, 92037, USA.
Jan H SpilleDepartment of Physics, University of Illinois Chicago, Chicago, IL, 60607, USA.ORCID http://orcid.org/0000-0001-8493-4721
Amy L KenterDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, 60612-7344, USA. star1@uic.edu.ORCID http://orcid.org/0000-0003-1419-5550

Funding

Chromatin infrastructure of the Igh locus and its influence on VH gene usageR01AI121286 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENTER, AMY L · 2016 to 2020
$4.2M
Impact of novel enhancers on Igh repertoire diversityR01AI177507 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENTER, AMY L · 2023 to 2025
$2.4M
NIAID NIH HHS R01 AI121286NIAID NIH HHS R01 AI177507
6 · The paper itself

Abstract

Igh locus positioning in the nuclear center is correlated with V to DJ recombination. However, the mechanisms that dictate radial positioning remain undefined. Deletion of the highly transcribed V

Indexed as

Cell NucleusImmunoglobulin Heavy ChainsV(D)J RecombinationAllelesAnimalsIn Situ Hybridization, FluorescenceMiceImmunoglobulin Heavy Chains

Identifiers

PMID42010249
PMCPMC13280346

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.