Evidence map›Paper›PMID 42010212›Full record

SynthesisJournal of robotic surgery2026

Partial versus radical nephrectomy for pT3a renal cell carcinoma: a systematic review and meta-analysis.

Filippo Gavi, Francesco Rossi, Daniele Fettucciari, Giuseppe Pallotta, Antonio Silvestri, Cristina Carerj, Vincenzo Cavarra, Domenico Sanesi, Francesco Pio Bizzarri, Marco Montesi and 8 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of robotic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Filippo Gavi *Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Francesco RossiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy. dottorfrancescorossi@gmail.com.
Daniele FettucciariDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Giuseppe PallottaDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Antonio SilvestriDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Cristina CarerjDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Vincenzo CavarraDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Domenico SanesiUniversità Cattolica del Sacro Cuore, Rome, Italy.
Francesco Pio BizzarriDepartment of Urology, Isola Tiberina - Gemelli Isola Hospital, Rome, Italy.
Marco MontesiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Simone AssummaDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Enrico PanioDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Pierluigi RussoDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Mauro RagoneseDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Nazario FoschiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Filippo TurriDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Maria Chiara SighinolfiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Bernardo RoccoDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The surgical management of pathologic T3a (pT3a) renal cell carcinoma (RCC) remains contentious due to the lack of high-level evidence guiding the choice between partial nephrectomy (PN) and radical nephrectomy (RN). This systematic review and meta-analysis aims to evaluate whether PN represents a safe and effective alternative to RN. A comprehensive search of PubMed, Web of Science, and Scopus was conducted through July 2025. The study included comparative trials of adult pT3a RCC patients undergoing PN or RN, focusing on oncological, perioperative, and functional outcomes. Sixteen retrospective studies involving 34,304 patients (5878 PN; 28426 RN) were analyzed. There were no statistically significant differences between PN and RN regarding estimated blood loss, operative time, hospital stay, or major postoperative complications (Clavien-Dindo > 2). PN was associated with significantly better preservation of renal function (9.96; I2 0%; p < 0.01), higher rate of positive surgical margins (0.82; I2 49.2%; p < 0.01), lower tumor size (-2.6; I2 99.4%; p < 0.01). PN is a safe and feasible alternative for pT3a RCC cases, providing superior functional preservation without compromising perioperative safety or oncological control.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsNephrectomyHumansLength of StayNeoplasm StagingOperative TimePostoperative ComplicationsTreatment OutcomeKidneyLocally advancedPartial nephrectomyRadical nephrectomyRenal cancerSurgery

Identifiers

PMID42010212
PMCPMC13095967

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.