ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2026
Platelet count, liver and spleen stiffness-based model reliably identifies esophageal varices needing treatment in acute-on-chronic liver failure.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The emerging role of the PLiST model in acute-on-chronic liver failure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Author's Reply: Reconsidering splenic stiffness measurement for non-invasive esophageal variceal screening in cirrhosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Reconsidering splenic stiffness measurement for non-invasive esophageal variceal screening in cirrhosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
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9 authors.
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Abstract
BACKGROUND AND
objectivesTransient elastography of liver and spleen, along with platelet count, identify cirrhosis patients with esophageal varices needing treatment (VNT). Inflammation can drive rapid rise in portal pressure and development and progression of varices in acute-on-chronic liver failure (ACLF) patients. We aimed at developing a non-invasive model to predict VNT in ACLF patients.
methodsBaseline liver stiffness measurement (LSM) and spleen stiffness measurement (SSM) were done using Fibroscan 630 Expert and esophagogastroduodenoscopy was performed to detect VNT. Varices with red color signs or large size were considered VNT. A model was developed and validated. Decision curve analysis (DCA) was used to assess net benefit (NB) of model at different threshold probabilities.
resultsOf the 216 patients analyzed (males 95.4%, mean age 42.2 yr, model for end-stage liver disease [MELD] score 25.5, alcohol etiology 83.4%), 104 (48.14%) had VNT. Patients with VNT had higher SSM (kPa) (76.71 ± 17.54 vs. 60.56 ± 20.21, p = 0.006), LSM (kPa) (71.96 ± 6.87 vs. 61.93 ± 17.76, p = 0.001) and lower platelet count (10
conclusionA model comprising SSM, LSM and platelet count identifies VNT non-invasively in ACLF patients.
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