Evidence map›Paper›PMID 42010186›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2026

Limited Potential to Reverse Deafness Caused by Mutation of Myo7a.

Daniel R Pentland, Jack Blackburn, Lauren Witting, Darcey A Kirwin, Karen P Steel

Abstract read
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In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel R PentlandWolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London, SE1 1UL, UK.
Jack BlackburnWolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London, SE1 1UL, UK.
Lauren WittingWolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London, SE1 1UL, UK.
Darcey A KirwinWolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London, SE1 1UL, UK.
Karen P SteelWolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London, SE1 1UL, UK. karen.steel@kcl.ac.uk.ORCID http://orcid.org/0000-0002-8019-5359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMYO7A is involved in several forms of deafness in humans and mice, and in this study we aimed to investigate if the hearing loss could be reversed after its onset.

methodsA knockdown allele of Myo7a in the mouse, Myo7a

resultsMyo7a

conclusionsIt is likely to be challenging to reverse hearing loss due to very early developmental defects of stereocilia organisation.

Indexed as

DeafnessMutationMyosinsAnimalsEvoked Potentials, Auditory, Brain StemHair Cells, AuditoryMiceMicroscopy, Electron, ScanningMyosin VIIaStereociliaMyo7a protein, mouseMyosinsMyosin VIIaGeneticsHearing loss reversalMouseMyo7a

Identifiers

PMID42010186
PMCPMC7619100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.