ArticleJournal of materials science. Materials in medicine2026
Therapeutic effects of an engineered bionic decoy-integrated versatile immunosuppressive nanosystem based on an in vitro blood-brain barrier model in ischemic stroke.
Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundStroke is a class of acute cerebrovascular diseases, among which ischaemic stroke is characterized by high morbidity and high recurrence rate. Due to multiple pathological mechanisms, it is very easy to cause cerebral ischaemia-reperfusion injury (RI). To quickly and effectively regulate the complex and variable cerebral immune microenvironment (IM) and reduce RI, the study aims to use a versatile immunosuppressive nanosystem (VIN) to efficiently remodel the overactivated brain IM and alleviate RI, thereby enhancing the effects of ischemic stroke (IS).
methodsThe study first induced high expression of CXCR4 receptor in rat bone marrow mesenchymal stem cell membranes using Fe
resultsIt was shown that Fe
conclusionThe study achieved internal and external synergistic immunosuppressive effects to effectively and safely regulate the excessive IM after reperfusion, which provides a new idea to alleviate ischaemia-RI.
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