Evidence map›Paper›PMID 42010012›Full record

ArticleNature plants2026

Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis.

Guillaume Gilliard, Jelena Pršić, Jean-Marc Crowet, Catherine Chemotti, Jahed Ahmed, Joseph Lorent, Marie-Dominique Jolivet, Sabrina Egli, Stéphane Egée, Guillaume Bouyer and 36 more

Erratum issuedAbstract read
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Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

46 authors.

Guillaume Gilliard *Laboratory of Molecular Biophysics at Interfaces, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.ORCID http://orcid.org/0000-0002-4651-2920
Jelena Pršić *Microbial Processes and Interactions laboratory, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.ORCID http://orcid.org/0000-0002-3943-7491
Jean-Marc CrowetMAgICS, MEDyC, CNRS UMR 7369 UFR Sciences Exactes et Naturelles, University of Reims Champagne-Ardenne, Reims, France.ORCID http://orcid.org/0000-0002-9252-2396
Catherine ChemottiLaboratory of Molecular Biophysics at Interfaces, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Jahed AhmedLaboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France.
Joseph LorentCellular and Molecular Pharmacology, Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.ORCID http://orcid.org/0000-0002-7537-8521
Marie-Dominique JolivetPlant Cell Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Sabrina EgliInstitute of Cell and Interaction Biology, CEPLAS Cluster of Excellence on Plant Sciences, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-5005-0127
Stéphane EgéeUMR8227 LBI2M Sorbonne Université-CNRS, Station Biologique de Roscoff, Roscoff, France.ORCID http://orcid.org/0000-0002-6195-4639
Guillaume BouyerUMR8227 LBI2M Sorbonne Université-CNRS, Station Biologique de Roscoff, Roscoff, France.ORCID http://orcid.org/0000-0002-5808-0539
Gaëlle RaceMicrobial Processes and Interactions laboratory, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Lennard van BurenDivision of Plant Biotechnics, Department of Biosystems, KU Leuven and KU Leuven Plant Institute, Heverlee, Belgium.ORCID http://orcid.org/0000-0001-5649-8096
Anke Van Den BergheDivision of Plant Biotechnics, Department of Biosystems, KU Leuven and KU Leuven Plant Institute, Heverlee, Belgium.ORCID http://orcid.org/0009-0004-7912-5777
Anthony Argüelles-AriasMicrobial Processes and Interactions laboratory, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Marion Mathelié-GuinletInstitute of Biomolecular Science and Technology, Catholic University of Louvain, Louvain-la-Neuve, Belgium.ORCID http://orcid.org/0000-0001-9023-3470
Heba IbrahimDivision of Plant Biotechnics, Department of Biosystems, KU Leuven and KU Leuven Plant Institute, Heverlee, Belgium.ORCID http://orcid.org/0000-0003-0603-7755
Manon GenvaLaboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Laetitia FouillenLaboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France.ORCID http://orcid.org/0000-0002-1204-9296
Cécile Mirande-BretLaboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France.
Oihana RazinLaboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France.
Brian VueLaboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France.
Milan ŽupunskiInstitute of Cell and Interaction Biology, CEPLAS Cluster of Excellence on Plant Sciences, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-8576-1292
W Patricio Luzuriaga-LoaizaMicrobial Processes and Interactions laboratory, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Estelle DeboeverLaboratory of Molecular Biophysics at Interfaces, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
M Nail NasirLaboratory of Molecular Biophysics at Interfaces, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.ORCID http://orcid.org/0000-0003-3429-9445
Laurence LinsLaboratory of Molecular Biophysics at Interfaces, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Patrick Van Der SmissenCELL Unit, De Duve Institute, UCLouvain, Brussels, Belgium.
Farah BoubsiMicrobial Processes and Interactions laboratory, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Sabine EschrigSchool of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Véronique GermainLaboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France.
Monica HöfteLaboratory of Phytopathology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-0850-3249
Cyril ZipfelDepartment of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-4935-8583
Yves F DufrêneDivision of Plant Biotechnics, Department of Biosystems, KU Leuven and KU Leuven Plant Institute, Heverlee, Belgium.ORCID http://orcid.org/0000-0002-7289-4248
Donatienne TytecaCELL Unit, De Duve Institute, UCLouvain, Brussels, Belgium.
Alexandros KoutsioubasJülich Centre for Neutron Science at Heinz Maier-Leibnitz Zentrum, Forschungszentrum Jülich GmbH, Garching, Germany.ORCID http://orcid.org/0000-0001-9417-5108
Paola BroccaDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Segrate, Italy.ORCID http://orcid.org/0000-0002-9852-6056
Guido GrossmannInstitute of Cell and Interaction Biology, CEPLAS Cluster of Excellence on Plant Sciences, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-7529-9244
Stefanie RanfDepartment of Biology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Stephan DoreyRIBP, UMR INRAE 1488, EXEBIO Institute, University of Reims Champagne-Ardenne, Reims, France.ORCID http://orcid.org/0000-0002-9583-2824
Barbara De ConinckDivision of Plant Biotechnics, Department of Biosystems, KU Leuven and KU Leuven Plant Institute, Heverlee, Belgium.
Thorsten NürnbergerCentre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Tübingen, Germany.
Sébastien MongrandLaboratoire de Biogenèse Membranaire, University of Bordeaux, Villenave d'Ornon, France.ORCID http://orcid.org/0000-0002-9198-015X
Julien GronnierPlant Cell Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0002-1429-0542
Valeria RondelliDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Segrate, Italy.ORCID http://orcid.org/0000-0001-8409-9025
Magali DeleuLaboratory of Molecular Biophysics at Interfaces, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium. magali.deleu@uliege.be.ORCID http://orcid.org/0000-0001-8255-2965
Marc OngenaMicrobial Processes and Interactions laboratory, TERRA Research Centre, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium. marc.ongena@uliege.be.ORCID http://orcid.org/0000-0002-7418-4354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria-derived lipopeptides are immunogenic triggers of host defences in metazoans and plants. Root-associated rhizobacteria produce cyclic lipopeptides that activate induced systemic resistance against microbial infection in various plant species. Whether and how these molecules are perceived at the plant cell surface remains elusive. Here we reveal that immune activation in Arabidopsis thaliana by the lipopeptide elicitor surfactin is mediated via a specific interaction with membrane sphingolipids. It relies on host membrane remodelling and subsequent activation of mechanosensitive ion channels. This mechanism leads to host defence potentiation and resistance to the necrotrophic fungus Botrytis cinerea and appears distinct from pattern-triggered immunity induced by classical host pattern recognition receptors. These results reveal a previously uncharacterized mechanism through which lipopeptides derived from non-pathogenic bacteria activate plant immune responses.

Indexed as

ArabidopsisCell MembraneLipopeptidesPeptides, CyclicPlant ImmunityArabidopsis ProteinsBotrytisInnate Immunity RecognitionPlant DiseasesSphingolipidsArabidopsis ProteinsLipopeptidesPeptides, CyclicSphingolipids

Identifiers

PMID42010012
PMCPMC13197228

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.