ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
Lower calcium/phosphorus ratio is associated with the severity of deformity in patients with scoliosis.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
objectiveTo explore the association between the serum calcium/phosphorus Ratio and the severity of spinal deformity in scoliosis patients and its clinical significance.
methodsBased on retrospective cohort data from 141 non-surgically treated scoliosis patients at Department of Spine Surgery at Guangzhou First People’s Hospital between 2019 and 2025, the Ca/P Ratio and spinal deformity severity were analyzed. Multivariable logistic regression, restricted cubic spline (RCS) analysis, and subgroup analyses were conducted to assess the independent association between the Ca/P Ratio and deformity severity. Adjustments were performed for confounders to improve the validity of the findings.
resultsPatients in the highest Ca/P Ratio quartile (Q4) exhibited significantly milder spinal deformity (P<0.001). Multivariable analysis demonstrated that each unit increase in the Ca/P Ratio was associated with a reduced risk of severe deformity (OR=0.25, 95% CI: 0.07-0.92, P=0.037). RCS analysis revealed a nonlinear association between the Ca/P Ratio and deformity severity (nonlinear P=0.0495). Subgroup analyses indicated that the protective effect was more pronounced in patients without hypertension/diabetes, males, those with lower BMI, or lower bone mineral density.
conclusionThe serum Ca/P Ratio is an independent predictor of spinal deformity severity in scoliosis patients. Its imbalance may exacerbate spinal structural abnormalities by affecting bone metabolism.
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