Evidence map›Paper›PMID 42009897›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2026

Effect modification of late surfactant treatment by patent ductus arteriosus status in ventilated preterm infants: a secondary analysis of a randomized clinical trial.

Patrick J Peebles, Jens C Eickhoff, Timothy G Elgin, Anudeepa Sharma, Nicolas A Bamat, Jonathan M Klein, Patrick J McNamara, Roberta L Keller, Dinushan C Kaluarachchi

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrick J PeeblesDivision of Neonatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. pjpeebles@wisc.edu.ORCID http://orcid.org/0000-0002-9724-9456
Jens C EickhoffDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Timothy G ElginDivision of Neonatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Anudeepa SharmaDivision of Neonatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Nicolas A BamatDivision of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6427-093X
Jonathan M KleinDivision of Neonatology, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-6693-1823
Patrick J McNamaraDivision of Neonatology, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-7648-8872
Roberta L KellerDivision of Neonatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0743-8470
Dinushan C KaluarachchiDivision of Neonatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID http://orcid.org/0000-0001-8334-6282

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether the effect of late surfactant is modified by patent ductus arteriosus (PDA) status with respect to survival without bronchopulmonary dysplasia (BPD) in ventilated infants born <28 weeks' gestation.

methodsSecondary analysis of the Trial of Late Surfactant (TOLSURF). A formal test of interaction between PDA presence and late surfactant, with respect to survival without BPD at 36 and 40 weeks' postmenstrual age (PMA), was performed. PDA presence was defined by PDA treatment, either medical or a ligation (definition A), or PDA ligation (definition B), during or after late surfactant administration.

resultsAll 511 infants were included. No interaction was detected between a PDA and late surfactant for survival without BPD at 36 weeks' PMA (definition A: p = 0.41; definition B: p = 0.33), or at 40 weeks' PMA (definition A: p = 0.84; definition B: p = 0.42).

conclusionPDA presence did not modify the effect of late surfactant for survival without BPD.

Indexed as

Bronchopulmonary DysplasiaDuctus Arteriosus, PatentPulmonary SurfactantsRespiration, ArtificialRespiratory Distress Syndrome, NewbornFemaleGestational AgeHumansInfant, NewbornInfant, PrematureLigationMaleSecondary Data AnalysisPulmonary Surfactants

Identifiers

PMID42009897
PMCPMC13423787

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.